The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC.
Identifieur interne : 000257 ( Main/Exploration ); précédent : 000256; suivant : 000258The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC.
Auteurs : Christian Manegold [Allemagne] ; Anne-Marie C. Dingemans [Pays-Bas] ; Jhanelle E. Gray [États-Unis] ; Kazuhiko Nakagawa [Japon] ; Marianne Nicolson [Royaume-Uni] ; Solange Peters [Suisse] ; Martin Reck [Allemagne] ; Yi-Long Wu [République populaire de Chine] ; Odd Terje Brustugun [Norvège] ; Lucio Crin [Italie] ; Enriqueta Felip [Espagne] ; Dean Fennell [Royaume-Uni] ; Pilar Garrido [Espagne] ; Rudolf M. Huber [Allemagne] ; Aurélien Marabelle [France] ; Marcin Moniuszko [Pologne] ; Françoise Mornex [France] ; Silvia Novello [Italie] ; Mauro Papotti [Italie] ; Maurice Pérol [France] ; Egbert F. Smit [Pays-Bas] ; Kostas Syrigos [Grèce] ; Jan P. Van Meerbeeck [Belgique] ; Nico Van Zandwijk [Australie] ; James Chih-Hsin Yang [Taïwan] ; Caicun Zhou [République populaire de Chine] ; Everett Vokes [États-Unis]Source :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [ 1556-1380 ] ; 2017.
Abstract
Over the past few years, there have been considerable advances in the treatments available to patients with metastatic or locally advanced NSCLC, particularly those who have progressed during first-line treatment. Some of the treatment options available to patients are discussed here, with a focus on checkpoint inhibitor immunotherapies (nivolumab and pembrolizumab) and antiangiogenic agents (bevacizumab, ramucirumab, and nintedanib). It is hypothesized that combining immunotherapy with antiangiogenic treatment may have a synergistic effect and enhance the efficacy of both treatments. In this review, we explore the theory and potential of this novel treatment option for patients with advanced NSCLC. We discuss the growing body of evidence that proangiogenic factors can modulate the immune response (both by reducing T-cell infiltration into the tumor microenvironment and through systemic effects on immune-regulatory cell function), and we examine the preclinical evidence for combining these treatments. Potential challenges are also considered, and we review the preliminary evidence of clinical efficacy and safety with this novel combination in a variety of solid tumor types.
DOI: 10.1016/j.jtho.2016.10.003
PubMed: 27729297
Affiliations:
- Allemagne, Australie, Belgique, Espagne, France, Grèce, Italie, Japon, Norvège, Pays-Bas, Pologne, Royaume-Uni, République populaire de Chine, Suisse, Taïwan, États-Unis
- Attique (région), Auvergne-Rhône-Alpes, Bade-Wurtemberg, Bavière, Canton de Vaud, Catalogne, Communauté de Madrid, District de Haute-Bavière, District de Karlsruhe, Floride, Guangdong, Hollande-Septentrionale, Illinois, Nouvelle-Galles du Sud, Piémont, Rhône-Alpes, Østlandet
- Amsterdam, Athènes, Barcelone, Heidelberg, Jiangmen, Lausanne, Lyon, Madrid, Munich, Oslo, Sydney, Turin
- Université Louis-et-Maximilien de Munich, Université de Sydney
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xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic Oncology, Lung Clinic Grosshansdorf, Airway Research Center North, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name><affiliation wicri:level="3"><nlm:affiliation>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Crin, Lucio" sort="Crin, Lucio" uniqKey="Crin L" first="Lucio" last="Crin">Lucio Crin</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, Perugia University Medical School, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology Department, Perugia University Medical School, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Felip, Enriqueta" sort="Felip, Enriqueta" uniqKey="Felip E" first="Enriqueta" last="Felip">Enriqueta Felip</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fennell, Dean" sort="Fennell, Dean" uniqKey="Fennell D" first="Dean" last="Fennell">Dean Fennell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Leicester and Leicester University Hospitals, Leicester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Leicester and Leicester University Hospitals, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Garrido, Pilar" sort="Garrido, Pilar" uniqKey="Garrido P" first="Pilar" last="Garrido">Pilar Garrido</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Oncología Médica, IRYCIS Hospital Universitario Ramón y Cajal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Oncología Médica, IRYCIS Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Huber, Rudolf M" sort="Huber, Rudolf M" uniqKey="Huber R" first="Rudolf M" last="Huber">Rudolf M. Huber</name><affiliation wicri:level="4"><nlm:affiliation>Ludwig-Maximilians-Universität München, University Hospital, Division of Respiratory Medicine and Thoracic Oncology, Münich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ludwig-Maximilians-Universität München, University Hospital, Division of Respiratory Medicine and Thoracic Oncology, Münich</wicri:regionArea><wicri:noRegion>Münich</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Marabelle, Aurelien" sort="Marabelle, Aurelien" uniqKey="Marabelle A" first="Aurélien" last="Marabelle">Aurélien Marabelle</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, Université Paris-Saclay, Département d'Innovation Thérapeutique et d'Essais Précoces, INSERM U1015, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, Université Paris-Saclay, Département d'Innovation Thérapeutique et d'Essais Précoces, INSERM U1015, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Moniuszko, Marcin" sort="Moniuszko, Marcin" uniqKey="Moniuszko M" first="Marcin" last="Moniuszko">Marcin Moniuszko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Mornex, Francoise" sort="Mornex, Francoise" uniqKey="Mornex F" first="Françoise" last="Mornex">Françoise Mornex</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Université Claude Bernard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Université Claude Bernard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Novello, Silvia" sort="Novello, Silvia" uniqKey="Novello S" first="Silvia" last="Novello">Silvia Novello</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Papotti, Mauro" sort="Papotti, Mauro" uniqKey="Papotti M" first="Mauro" last="Papotti">Mauro Papotti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Perol, Maurice" sort="Perol, Maurice" uniqKey="Perol M" first="Maurice" last="Pérol">Maurice Pérol</name><affiliation wicri:level="3"><nlm:affiliation>Département de Cancérologie, Médicale Centre Léon Bérard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Cancérologie, Médicale Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Smit, Egbert F" sort="Smit, Egbert F" uniqKey="Smit E" first="Egbert F" last="Smit">Egbert F. Smit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Diseases and Department of Thoracic Oncology, VU University Medical Centre, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pulmonary Diseases and Department of Thoracic Oncology, VU University Medical Centre, Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Syrigos, Kostas" sort="Syrigos, Kostas" uniqKey="Syrigos K" first="Kostas" last="Syrigos">Kostas Syrigos</name><affiliation wicri:level="3"><nlm:affiliation>Oncology Unit GPP, Sotiria General Hospital, Athens University School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Oncology Unit GPP, Sotiria General Hospital, Athens University School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Van Meerbeeck, Jan P" sort="Van Meerbeeck, Jan P" uniqKey="Van Meerbeeck J" first="Jan P" last="Van Meerbeeck">Jan P. Van Meerbeeck</name><affiliation wicri:level="1"><nlm:affiliation>Thoracic Oncology, Antwerp University Hospital and Ghent University, Edegem, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Thoracic Oncology, Antwerp University Hospital and Ghent University, Edegem</wicri:regionArea><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Van Zandwijk, Nico" sort="Van Zandwijk, Nico" uniqKey="Van Zandwijk N" first="Nico" last="Van Zandwijk">Nico Van Zandwijk</name><affiliation wicri:level="4"><nlm:affiliation>Asbestos Diseases Research Institute, University of Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Asbestos Diseases Research Institute, University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Chih Hsin Yang, James" sort="Chih Hsin Yang, James" uniqKey="Chih Hsin Yang J" first="James" last="Chih-Hsin Yang">James Chih-Hsin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Caicun" sort="Zhou, Caicun" uniqKey="Zhou C" first="Caicun" last="Zhou">Caicun Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Shanghai Pulmonary Hospital, Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, Shanghai Pulmonary Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Vokes, Everett" sort="Vokes, Everett" uniqKey="Vokes E" first="Everett" last="Vokes">Everett Vokes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Chicago Medical Center, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Medicine, University of Chicago Medical Center, Chicago</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27729297</idno><idno type="pmid">27729297</idno><idno type="doi">10.1016/j.jtho.2016.10.003</idno><idno type="wicri:Area/PubMed/Corpus">001116</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001116</idno><idno type="wicri:Area/PubMed/Curation">001113</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001113</idno><idno type="wicri:Area/PubMed/Checkpoint">001113</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001113</idno><idno type="wicri:Area/Ncbi/Merge">003C92</idno><idno type="wicri:Area/Ncbi/Curation">003C92</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C92</idno><idno type="wicri:Area/Main/Merge">000252</idno><idno type="wicri:Area/Main/Curation">000257</idno><idno type="wicri:Area/Main/Exploration">000257</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC.</title><author><name sortKey="Manegold, Christian" sort="Manegold, Christian" uniqKey="Manegold C" first="Christian" last="Manegold">Christian Manegold</name><affiliation wicri:level="3"><nlm:affiliation>Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. Electronic address: prof.manegold@t-online.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Faculty Mannheim, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dingemans, Anne Marie C" sort="Dingemans, Anne Marie C" uniqKey="Dingemans A" first="Anne-Marie C" last="Dingemans">Anne-Marie C. Dingemans</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary Diseases, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pulmonary Diseases, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Gray, Jhanelle E" sort="Gray, Jhanelle E" uniqKey="Gray J" first="Jhanelle E" last="Gray">Jhanelle E. Gray</name><affiliation wicri:level="2"><nlm:affiliation>Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Nakagawa, Kazuhiko" sort="Nakagawa, Kazuhiko" uniqKey="Nakagawa K" first="Kazuhiko" last="Nakagawa">Kazuhiko Nakagawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Nicolson, Marianne" sort="Nicolson, Marianne" uniqKey="Nicolson M" first="Marianne" last="Nicolson">Marianne Nicolson</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oncology Department, Aberdeen Royal Infirmary, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Solange" sort="Peters, Solange" uniqKey="Peters S" first="Solange" last="Peters">Solange Peters</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Reck, Martin" sort="Reck, Martin" uniqKey="Reck M" first="Martin" last="Reck">Martin Reck</name><affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Oncology, Lung Clinic Grosshansdorf, Airway Research Center North, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic Oncology, Lung Clinic Grosshansdorf, Airway Research Center North, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name><affiliation wicri:level="3"><nlm:affiliation>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Crin, Lucio" sort="Crin, Lucio" uniqKey="Crin L" first="Lucio" last="Crin">Lucio Crin</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, Perugia University Medical School, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology Department, Perugia University Medical School, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Felip, Enriqueta" sort="Felip, Enriqueta" uniqKey="Felip E" first="Enriqueta" last="Felip">Enriqueta Felip</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fennell, Dean" sort="Fennell, Dean" uniqKey="Fennell D" first="Dean" last="Fennell">Dean Fennell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Leicester and Leicester University Hospitals, Leicester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Leicester and Leicester University Hospitals, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Garrido, Pilar" sort="Garrido, Pilar" uniqKey="Garrido P" first="Pilar" last="Garrido">Pilar Garrido</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Oncología Médica, IRYCIS Hospital Universitario Ramón y Cajal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Oncología Médica, IRYCIS Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Huber, Rudolf M" sort="Huber, Rudolf M" uniqKey="Huber R" first="Rudolf M" last="Huber">Rudolf M. Huber</name><affiliation wicri:level="4"><nlm:affiliation>Ludwig-Maximilians-Universität München, University Hospital, Division of Respiratory Medicine and Thoracic Oncology, Münich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ludwig-Maximilians-Universität München, University Hospital, Division of Respiratory Medicine and Thoracic Oncology, Münich</wicri:regionArea><wicri:noRegion>Münich</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Marabelle, Aurelien" sort="Marabelle, Aurelien" uniqKey="Marabelle A" first="Aurélien" last="Marabelle">Aurélien Marabelle</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, Université Paris-Saclay, Département d'Innovation Thérapeutique et d'Essais Précoces, INSERM U1015, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, Université Paris-Saclay, Département d'Innovation Thérapeutique et d'Essais Précoces, INSERM U1015, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Moniuszko, Marcin" sort="Moniuszko, Marcin" uniqKey="Moniuszko M" first="Marcin" last="Moniuszko">Marcin Moniuszko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Mornex, Francoise" sort="Mornex, Francoise" uniqKey="Mornex F" first="Françoise" last="Mornex">Françoise Mornex</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Université Claude Bernard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Université Claude Bernard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Novello, Silvia" sort="Novello, Silvia" uniqKey="Novello S" first="Silvia" last="Novello">Silvia Novello</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Papotti, Mauro" sort="Papotti, Mauro" uniqKey="Papotti M" first="Mauro" last="Papotti">Mauro Papotti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Perol, Maurice" sort="Perol, Maurice" uniqKey="Perol M" first="Maurice" last="Pérol">Maurice Pérol</name><affiliation wicri:level="3"><nlm:affiliation>Département de Cancérologie, Médicale Centre Léon Bérard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Cancérologie, Médicale Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Smit, Egbert F" sort="Smit, Egbert F" uniqKey="Smit E" first="Egbert F" last="Smit">Egbert F. Smit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Diseases and Department of Thoracic Oncology, VU University Medical Centre, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pulmonary Diseases and Department of Thoracic Oncology, VU University Medical Centre, Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Syrigos, Kostas" sort="Syrigos, Kostas" uniqKey="Syrigos K" first="Kostas" last="Syrigos">Kostas Syrigos</name><affiliation wicri:level="3"><nlm:affiliation>Oncology Unit GPP, Sotiria General Hospital, Athens University School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Oncology Unit GPP, Sotiria General Hospital, Athens University School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Van Meerbeeck, Jan P" sort="Van Meerbeeck, Jan P" uniqKey="Van Meerbeeck J" first="Jan P" last="Van Meerbeeck">Jan P. Van Meerbeeck</name><affiliation wicri:level="1"><nlm:affiliation>Thoracic Oncology, Antwerp University Hospital and Ghent University, Edegem, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Thoracic Oncology, Antwerp University Hospital and Ghent University, Edegem</wicri:regionArea><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Van Zandwijk, Nico" sort="Van Zandwijk, Nico" uniqKey="Van Zandwijk N" first="Nico" last="Van Zandwijk">Nico Van Zandwijk</name><affiliation wicri:level="4"><nlm:affiliation>Asbestos Diseases Research Institute, University of Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Asbestos Diseases Research Institute, University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Chih Hsin Yang, James" sort="Chih Hsin Yang, James" uniqKey="Chih Hsin Yang J" first="James" last="Chih-Hsin Yang">James Chih-Hsin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Caicun" sort="Zhou, Caicun" uniqKey="Zhou C" first="Caicun" last="Zhou">Caicun Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Shanghai Pulmonary Hospital, Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, Shanghai Pulmonary Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Vokes, Everett" sort="Vokes, Everett" uniqKey="Vokes E" first="Everett" last="Vokes">Everett Vokes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Chicago Medical Center, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Medicine, University of Chicago Medical Center, Chicago</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</title><idno type="eISSN">1556-1380</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Over the past few years, there have been considerable advances in the treatments available to patients with metastatic or locally advanced NSCLC, particularly those who have progressed during first-line treatment. Some of the treatment options available to patients are discussed here, with a focus on checkpoint inhibitor immunotherapies (nivolumab and pembrolizumab) and antiangiogenic agents (bevacizumab, ramucirumab, and nintedanib). It is hypothesized that combining immunotherapy with antiangiogenic treatment may have a synergistic effect and enhance the efficacy of both treatments. In this review, we explore the theory and potential of this novel treatment option for patients with advanced NSCLC. We discuss the growing body of evidence that proangiogenic factors can modulate the immune response (both by reducing T-cell infiltration into the tumor microenvironment and through systemic effects on immune-regulatory cell function), and we examine the preclinical evidence for combining these treatments. Potential challenges are also considered, and we review the preliminary evidence of clinical efficacy and safety with this novel combination in a variety of solid tumor types.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Japon</li><li>Norvège</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suisse</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>Canton de Vaud</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Floride</li><li>Guangdong</li><li>Hollande-Septentrionale</li><li>Illinois</li><li>Nouvelle-Galles du Sud</li><li>Piémont</li><li>Rhône-Alpes</li><li>Østlandet</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Barcelone</li><li>Heidelberg</li><li>Jiangmen</li><li>Lausanne</li><li>Lyon</li><li>Madrid</li><li>Munich</li><li>Oslo</li><li>Sydney</li><li>Turin</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université de Sydney</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Manegold, Christian" sort="Manegold, Christian" uniqKey="Manegold C" first="Christian" last="Manegold">Christian Manegold</name></region><name sortKey="Huber, Rudolf M" sort="Huber, Rudolf M" uniqKey="Huber R" first="Rudolf M" last="Huber">Rudolf M. Huber</name><name sortKey="Reck, Martin" sort="Reck, Martin" uniqKey="Reck M" first="Martin" last="Reck">Martin Reck</name></country><country name="Pays-Bas"><noRegion><name sortKey="Dingemans, Anne Marie C" sort="Dingemans, Anne Marie C" uniqKey="Dingemans A" first="Anne-Marie C" last="Dingemans">Anne-Marie C. Dingemans</name></noRegion><name sortKey="Smit, Egbert F" sort="Smit, Egbert F" uniqKey="Smit E" first="Egbert F" last="Smit">Egbert F. Smit</name></country><country name="États-Unis"><region name="Floride"><name sortKey="Gray, Jhanelle E" sort="Gray, Jhanelle E" uniqKey="Gray J" first="Jhanelle E" last="Gray">Jhanelle E. Gray</name></region><name sortKey="Vokes, Everett" sort="Vokes, Everett" uniqKey="Vokes E" first="Everett" last="Vokes">Everett Vokes</name></country><country name="Japon"><noRegion><name sortKey="Nakagawa, Kazuhiko" sort="Nakagawa, Kazuhiko" uniqKey="Nakagawa K" first="Kazuhiko" last="Nakagawa">Kazuhiko Nakagawa</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Nicolson, Marianne" sort="Nicolson, Marianne" uniqKey="Nicolson M" first="Marianne" last="Nicolson">Marianne Nicolson</name></noRegion><name sortKey="Fennell, Dean" sort="Fennell, Dean" uniqKey="Fennell D" first="Dean" last="Fennell">Dean Fennell</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Peters, Solange" sort="Peters, Solange" uniqKey="Peters S" first="Solange" last="Peters">Solange Peters</name></region></country><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name></region><name sortKey="Zhou, Caicun" sort="Zhou, Caicun" uniqKey="Zhou C" first="Caicun" last="Zhou">Caicun Zhou</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name></region></country><country name="Italie"><noRegion><name sortKey="Crin, Lucio" sort="Crin, Lucio" uniqKey="Crin L" first="Lucio" last="Crin">Lucio Crin</name></noRegion><name sortKey="Novello, Silvia" sort="Novello, Silvia" uniqKey="Novello S" first="Silvia" last="Novello">Silvia Novello</name><name sortKey="Papotti, Mauro" sort="Papotti, Mauro" uniqKey="Papotti M" first="Mauro" last="Papotti">Mauro Papotti</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Felip, Enriqueta" sort="Felip, Enriqueta" uniqKey="Felip E" first="Enriqueta" last="Felip">Enriqueta Felip</name></region><name sortKey="Garrido, Pilar" sort="Garrido, Pilar" uniqKey="Garrido P" first="Pilar" last="Garrido">Pilar Garrido</name></country><country name="France"><noRegion><name sortKey="Marabelle, Aurelien" sort="Marabelle, Aurelien" uniqKey="Marabelle A" first="Aurélien" last="Marabelle">Aurélien Marabelle</name></noRegion><name sortKey="Mornex, Francoise" sort="Mornex, Francoise" uniqKey="Mornex F" first="Françoise" last="Mornex">Françoise Mornex</name><name sortKey="Perol, Maurice" sort="Perol, Maurice" uniqKey="Perol M" first="Maurice" last="Pérol">Maurice Pérol</name></country><country name="Pologne"><noRegion><name sortKey="Moniuszko, Marcin" sort="Moniuszko, Marcin" uniqKey="Moniuszko M" first="Marcin" last="Moniuszko">Marcin Moniuszko</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Syrigos, Kostas" sort="Syrigos, Kostas" uniqKey="Syrigos K" first="Kostas" last="Syrigos">Kostas Syrigos</name></region></country><country name="Belgique"><noRegion><name sortKey="Van Meerbeeck, Jan P" sort="Van Meerbeeck, Jan P" uniqKey="Van Meerbeeck J" first="Jan P" last="Van Meerbeeck">Jan P. Van Meerbeeck</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Van Zandwijk, Nico" sort="Van Zandwijk, Nico" uniqKey="Van Zandwijk N" first="Nico" last="Van Zandwijk">Nico Van Zandwijk</name></region></country><country name="Taïwan"><noRegion><name sortKey="Chih Hsin Yang, James" sort="Chih Hsin Yang, James" uniqKey="Chih Hsin Yang J" first="James" last="Chih-Hsin Yang">James Chih-Hsin Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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